Death From a Severe Nosebleed

Image by RIs from Wikipedia

Attila the Hun was one of the most feared enemies of the Roman Empire. Ruler of the Huns from the year 434 until his death in 452, his empire stretched from Ural River to the Rhine River and from the Danube River to the Baltic Sea.

Although there are numerous theories as to how he died, the conventional account is that he died from a severe nosebleed on his wedding night.

Some may scoff that only people in historical times die from nosebleeds... but it unfortunately still even happens in the present.

Yes... a life-threatening nosebleed can be fatal whether a historical figure like Attila or a modern day individual. And I am talking in people who are otherwise completely healthy (no hemophilia, ITP, Osler-Weber-Rendu, etc).

Indeed, a Seattle lawyer died from a nosebleed in 2008.

Two British individuals died from a nosebleed in 2008 and in 2011.

And those are just the ones that are reported in the media.

It is estimated that in 1999, 4 out of 2.4 million deaths in the United States was due to a nosebleed [link].

Fatal nosebleeds in a normal healthy individual are almost always due to an arterial bleed, notably the sphenopalatine artery located in the back of the nose. Other less common fatal nosebleeds may be attributable to the ethmoid arteries located in the top of the nasal cavity.

Treatment of such life-threathening nosebleeds depends on the situation, but may include:

• Nasal packing
• Embolization
• Surgical

Cautery as shown in the video below is rarely successful.

Sources:
Man died after suffering two-hour nose bleed. Mirror News 11/24/11

Man Dies From Severe Nosebleed. ABC News 12/2/11

Woman sues hospital after her husband dies of nosebleed. KOMONews 5/4/13

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Why Does EpiPen Have to be Injected into the Thigh?

As any severely food allergic patients know, when suffering from a potentially life-threatening anaphylactic reaction, they need to jab an epinephrine needle into the side of their thigh...

But... why the thigh? Why not the arm like most other shots?

Per AAAAI, there have been 3 anatomic sites investigated to determine which location offers the fastest systemic absorption of epinephrine when injected intramuscularly and/or subcutaneously.

• Intramuscular injection in the upper arm (deltoid muscle) just like a flu shot.
• Subcutaneous injection in the upper arm just like an allergy shot.
• Intramuscular injection in the lateral thigh (vastus lateralis muscle).

Of these sites, the intramuscular thigh injection demonstrated the fastest rise in blood epinephrine.

When dealing with a life-threatening anaphylaxis, you need the speed because if the drug is too slow, the person may die before adequate epinephrine levels are achieved... and the thigh muscle provides the speed whereas the other sites do not.

Why might that be?

It's probably because the thigh muscle is large with lots of blood vessels allowing for multiple points of access for the injected epinephrine to enter into the blood circulation.


References:
Epinephrine absorption in children with a history of anaphylaxis. J Allergy Clin Immunology 1998; 101(1):33-37.

Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol 2001; 108(5):871-873.

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