How Long Do Swallowing and Voice Problems Last After C-Spine Surgery ACDF?

I often see patients for swallowing and/or voice difficulties after cervical spine surgery (ACDF). In the vast majority of cases, reassurance that such "side effects" are not uncommon is the only thing I need to provide after a complete exam.

After all, both the voice box and swallowing tube are manipulated and pushed over to one side in order to perform cervical spine surgery from an anterior approach. Check out the video below that illustrates how this happens.

Beyond reassurance, the next question patients have is how long before things go back to normal. Until now, that was a hard question to answer.

A recent report was able to provide some numbers I can now use to help explain to patients. After anterior approaches to cervical spine surgery:

• 60% had a postoperative issue, including 27% with postoperative voice complaint and 48% with postoperative swallowing complaint
• Swallowing complaints that lasted beyond 1 year occurred in 28%
• Voice complaints that lasted over 1 year occurred in 9%
• Approaching spinal levels above C4 and exposing more than 3 spinal levels were 2 factors that significantly resulted in voice and swallowing problems

In certain patients with more extreme swallowing difficulties, barium swallow studies may be ordered. Swallow therapy can be helpful as well.

Should vocal cord paralysis be seen on endoscopy, voice therapy and even vocal cord medialization injections can be performed to alleviate voice problems.

Reference:
Factors Predictive of Voice and Swallowing Outcomes after Anterior Approaches to the Cervical Spine. Otolaryngol Head Neck Surg. 2013 Dec 23. [Epub ahead of print]

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Beatboxing Protective of the Vocal Cords?

Beatboxing is a popular vocal percussion technique that incorporates use of the entire vocal tract. Recently, research by Dr. Steven Simms (who I had the pleasure of working with briefly when we were both at Yale University in the 1990s) suggested that beatboxing techniques may actually protect against vocal cord injury.

Unlike singing where most of the sustained energy is directed at the vocal cord level, beatboxing makes extensive use of the entire vocal tract, especially the muscles of the throat.

Although more research is needed, it is not inconceivable that beatboxing techniques may potentially be helpful to patients who have suffered from vocal cord injury. The question is what techniques specifically and how it can be incorporated into voice therapy sessions. Furthermore, such vocal techniques may be more "acceptable" to teenagers who may scoff at more traditional strategies.

Check out this fiberoptic laryngoscopy video of a beatboxing artist.

Reference:
Functional Endoscopic Analysis of Beatbox Performers. Journal of Voice. Published Online 12/23/13. PII: S0892-1997(13)00243-9 doi:10.1016/j.jvoice.2013.11.007

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Acupuncture Helps with Ear Surgery Pain

Researchers at Boston Children's Hospital has found that acupuncture may be effective in diminishing both pain and post-anesthesia agitation in children after ear tube placement determined thru a prospective randomized controlled trial.

Typically, children are placed under general anesthesia in order to have this procedure performed and upon waking, are often tearful and agitated. In this study, acupuncture needles were placed at LI-4 and HT-7 immediately after anesthesia, but prior to ear tube placement.

A blinded assessor than determined that pain and agitation were significantly lower in the acupuncture group compared with controls during the 30 minutes after surgery. Furthermore, the number of patients who required analgesia was considerably lower in the acupuncture group than that in the control group.

Although promising, in order to be fully convinced of the effectiveness of acupuncture, further research by other groups in larger number of kids need to be performed.

BUT... because the risks and side effects are so nominal, it can't hurt to give it a try for those patients and families interested in doing so.

For full disclosure, I personally have no experience in providing acupuncture and I would suggest taking these research findings to a reputable and licensed acupuncturist to get this done in those who are interested.

Reference:
Acupuncture management of pain and emergence agitation in children after bilateral myringotomy and tympanostomy tube insertion. Pediatric Anesthesia. Volume 19, Issue 11, pages 1096–1101, November 2009

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Bengals Punter Kevin Huber Suffers Jaw Fracture During Game

Courtesy of Jeffrey Beall from Wikipedia

This past weekend, Cincinnati Bengals punter Mark Huber suffered a broken jaw when he was viciously knocked to the ground by Steelers Terence Gavin who lead the tackle with his helmet. [link]

Given bleeding from the mouth, there is the possibility of an open fracture extending into the mouth, though it could also be from a self-inflected bite when Huber got hit.

Unlike most facial fractures that do NOT require any surgical intervention, most jaw fractures do need to be surgically repaired and typically entail wiring the jaw shut. Often, a metal plate with screws will be utilized to stabilize the fracture as well.

The reason the jaw is wired shut is so that as the broken bone heals, it heals in such a way that the way the teeth comes together is normal (in essence, the teeth act as the cast for the jaw fracture). Of course, eating is limited to liquid diet and dental care is important as brushing the teeth thoroughly will be impossible.

Also, it is easier to precisely place the metal plates after the jaw is wired shut. In Huber's case, metal plates will almost certainly be utilized as it allows for faster healing, sooner removal of jaw wiring, and quicker return to normalcy.

The wires holding the jaw shut can be removed after a few weeks, but exact duration depends on the fracture location and severity.

With this type of facial fracture, it will be unclear when exactly he will be able to return play.

Source:
SEE IT: Bengals punter Kevin Huber fractures jaw after taking hit from Steelers' Terence Gavin. NY Daily News 12/15/13

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Acupuncture Alleviates Pain After Tonsillectomy in Children

The study showed that acupuncture significantly decreased pain after tonsillectomy in children (2-17 years of age) with reported pain levels before acupuncture of 5.52 (SD=2.28) out of 10 which fell to 1.92 (SD=2.43) after acupuncture.

This retrospective research was conducted in 31 patients who underwent a tonsillectomy within a 3 month period of time by Dr. James Ochi, one of only a handful of dual board-certified ENT and medical acupuncture in the United States. No study patients received any narcotics for pain control beyond tylenol, ibuprofen, and a single dose of intra-operative dexamethasone. The tonsillectomy itself was performed using electrocautery set at 24W.

The acupuncture points used for pain control are shown below and was performed bilaterally:

Image taken from the Research Paper

All patients received acupuncture at LI4 (between thumb and index finger). Additional points were found effective in relieving tonsillectomy pain and provided on an as needed basis at (in decreasing frequency) CV23, GV24.5 and GV20. Acupuncture points LI20, LI11, and LI10 were utilized in only a few patients.

LI4 point is hypothesized to work so well because:

"Stimulation at LI4 increases activity in the somatosensory cortex and a region of the brainstem known as the periaqueductal gray area, as revealed by functional magnetic resonance imaging, that are involved in processing pain signals." [link]

Although promising, in order to be fully convinced of the effectiveness of acupuncture for post-tonsillectomy pain, further research that is prospective, randomized, and controlled is required.

BUT... because the risks and side effects are so nominal, it can't hurt to give it a try for those patients and families interested in doing so.

For full disclosure, I personally have no experience in providing acupuncture and I would suggest taking these research findings to a reputable and licensed acupuncturist to get this done in those who are interested.


Reference:
Acupuncture instead of codeine for tonsillectomy pain in children. International Journal of Pediatric Otorhinolaryngology Volume 77, Issue 12 , Pages 2058-2062, December 2013

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Two New Sublingual Allergy Tablets Approved by FDA Advisory Committee

This week, the FDA Allergenic Products Advisory Committee unanimously supported approval for two new sublingual allergy tablets (Oralair and Grastek) that work the same way allergy shots do... but instead is dissolved under the tongue at home instead of a shot in the arm in a medical office. Although both tablets have been available in Europe for some time, final "official" FDA approval may not occur until end of 2014 (or later) for sale/distribution under prescription in the United States.

Oralair is made by a French pharmaceutical company Stallergenes and treats patients aged 10-65 years who are allergic to 5 different grasses: Sweet Vernal, Orchard, Perennial Rye, Timothy, and Kentucky Blue Grass. Treatment is composed of a buildup and maintenance phase. Starting 4 months prior to the grass pollen season, a 100 IR tablet is administered under the tongue in a medical office to ensure no significant side effects. At home on day 2, two 100 IR tablets are administered. On day three and daily thereafter, a 300 IR tablet is placed under the tongue until the end of the grass pollen season. The tablets take about 1 minute to dissolve.

Grastek (aka Grazax in Europe) is made by ALK-Abello and Merck and treats patients aged 5-65 years who are allergic to only Timothy Grass. Grastek has a simpler regimen of 1 sublingual tablet daily starting 12 weeks before and continued until the end of the grass pollen season. As with Oralair, the first dose is given in a medical office to ensure safety with all other doses are taken at home. The tablet dissolves in less than 10 seconds.

For both tablets, epipen needs to be available at home due to possible risk of anaphylaxis. As with allergy shots, patients on beta-blockers for high blood pressure are not eligible to undergo this treatment.

Sources:
Grastek Recommended by FDA Panel for Timothy Grass Allergy. Medscape 12/12/13

Sublingual Oralair Recommended for Grass Pollen Allergy. Medscape 12/11/13

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The Nose is a Jungle of Germs (even in Normal Healthy People)!

A fascinating study was conducted by Stanford researchers on the amount and types of germs found inside the nose in normal healthy individuals, whether they are staph carriers or not.

In a typical nose in a healthy individual without any symptoms, the following "germs" can be found. Keep in mind that ALL these germs have the potential to cause a pathological sinus infection:

• Corynebacterium
• Propionibacterium
• Escherichia-Shigella
• Staphylococcus aureus (including MRSA)
• Staphylococcus (other species)
• Dolosigranulum
• Tomitella
• Moraxella
• Actinobacteria
• beta-Proteobacteria
• Prevotella
• Anaerococcus
• Streptococcus
• Peptoniphilus
• Variovorax

These germs were found not just in the nostril, but also on the middle turbinate located about 1-2 inches into the nose and the sphenoid recess located in the very back upper part of the nose (about 3+ inches into the nose).

The top 2 most common germs found in healthy individuals were corynebacterium and propionibacterium. When these bacterial populations decrease, the presence of staphylococcus increases.

Staphylococcus was also found not just at the nostril where cultures are most commonly obtained, but in both much deeper locations within the nose.

This may explain why in spite of aggressive whole body MRSA body hygiene management and use of bactroban ointment to the nares not uncommonly fails to eradicate staph/MRSA in susceptible patients.

Clearly, more research is needed, especially in how to minimize/eradiacate staph colonization beyond the nostril (but allow for normal, healthy bacteria to remain).

Source:
Staph Germs Hide Out In The Hidden Recesses Of Your Nose. NPR 12/11/13

Reference:
Nasal Microenvironments and Interspecific Interactions Influence Nasal Microbiota Complexity and S. aureus Carriage. Cell Host & Microbe, Volume 14, Issue 6, 631-640, 11 December 2013

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Lawsuit for Botched Laser Vocal Cord Surgery

In February 2012, an ENT surgeon removed vocal cord polyps using a laser while the patient was asleep with a Medtronic Laser-Shield II endotracheal tube. Unfortunately, the laser perforated the endotracheal tube, ignited the 100% oxygen being used at the time resulting in catastrophic burns to the patient. [link]

Subsequent lawsuit resulted in favor of the patient who received an award totaling $30 million on 12/5/13.

What Happened?

Even though an endotracheal tube meant for use with laser procedures was utilized, if this specially designed tube sustains enough damage from the laser, it will either perforate or heat to a high enough temperature to ignite. Furthermore, 100% oxygen was administered by the anesthesiologist which just added gasoline to the flame.

Ideally, in such laser procedures, meticulous surgical technique is still required and care taken to avoid damaging the endotracheal tube, even if a "laser-safe" tube is used. The "weak" part of any laser-safe tube is the cuff that is inflated to make a tight seal between the trachea and the tube itself. As such, the cuff material is necessarily thin. Saline-soaked pledgets placed immediately above the cuff helps protect the cuff as well as use of a tube with two cuffs (in case one fails). Also, room air should have been administered to the patient in the event the tube fails in order to minimize oxygen in the area... and the patient placed temporarily on apnea whenever the laser is turned on.

The risk of fire among other reasons are why many ENT surgeons (myself included), have stopped using lasers for procedures done in the mouth and airway.

With vocal cord procedures, I still utilize cold steel techniques which has a zero risk of airway fire.

Sources:
Botched surgery will cost hospital. The Wenatchee World. 12/6/13.

Medtronic slips $18M verdict in surgical fire case. MassDevice. 12/10/13

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Tracheostomy Fire During Surgery Burning Patient

Image from Wikipedia

In early 2012, a surgeon was performing a trach (breathing hole in the neck) when the oxygen used during the procedure caught fire severely burning the patient. Apparently, the surgeon used an electrocautery device which most likely emitted a spark igniting the oxygen being given to the patient leading to the fire. [link]

What happened?

Tracheostomy procedures are performed typically in very sick patients who have been intubated for a prolonged period of time. Often, such patients require higher concentrations of oxygen than normal in order to maintain oxygen levels in the body.

Problem in this scenario is that higher concentrations of oxygen also mean a higher risk of accidental fire when using instruments that help stop bleeding like an electrocautery device.

During a tracheostomy, an opening is created in the windpipe (watch video below). This allows oxygen that is being given to the patient to leak out into the surgical field. If electrocautery is used in this oxygen rich environment, any spark from an electrocautery device can lead to ignition and a flash fire.

Typically, in order to minimize this risk of fire, the surgeon should avoid using any electrical instruments in the surgical field that may create a spark after entering into the airway. Cutting into the airway would allow oxygen to escape into the surgical field. That usually means meticulous surgical technique and controlling all bleeding BEFORE cutting into the airway. If possible, reducing the oxygen given to the patient as much as possible is also beneficial.

Nitrous oxide should be avoided as an anesthetic agent as it is also ignitable like oxygen.

If electocautery use is unavoidable after the airway is surgically entered, the endotracheal tube cuff should re-inflated and advanced past the tracheostomy incision. Vacuum suction should be applied to evacuate as much oxygen from the surgical field and if possible, a period of apnea while cautery is applied.


Source:
Revealed: The chief of surgery who set patient on fire when his electronic scalpel caused 'EXPLOSION' Mail Online. 5/6/12

References:
Airway fire during tracheostomy: prevention strategies for surgeons and anesthetists. Ann R Coll Surg Engl. 2001 November; 83(6): 376–380.

Fatal inhalation injury caused by airway fire during tracheostomy. Acta Anaesthesiol Scand. 2007 Apr;51(4):509-13.

Tracheostomal fire during an elective tracheostomy. Chang Gung Med J. 2005 Mar;28(3):186-90.

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Nasal Spray Cure for the Common Cold?

Well maybe not cure per se, but at least effective treatment to reduce the duration and severity of the viral cold at least. Austrian researchers have reported on the results of a randomized, double-blind, placebo-controlled trial involving 211 patients suffering from early symptoms of the common cold. [link]

Treatment of the non-placebo group involved using a nasal spray containing carrageenan (a sulphated polysaccharide found in red seaweed/algae) three times per day for 7 days. Cold symptoms were found to resolve 2.1 days faster and viral loads in the nasal washings were significantly decreased compared to placebo group. At day 21 of observation, one sixth of patients given the placebo were still ill, while only one twentieth were in the treatment group.

Personally, I would like to see larger studies conducted by other independent groups to verify the findings.

So how does this nasal spray work?

The problem with the common cold is that there are SO many viruses that manifest the same disease including rhinovirus, coronavirus, parainfluenza, influenza, respiratory syncytial virus, adenovirus, enterovirus, and metapneumovirus. As such, an effective treatment should be able to disable all these virus types and not just one.

The way carrageenan works is by sticking to the virus regardless of type and preventing it from attaching to the nasal lining. As such, the virus is unable to enter into the body and cause problems. It essentially blocks the virus like the wall of a castle.

The caveat is that in order for this nasal spray to work, you have to start using the medication as soon as cold symptoms appear (within 2 days). Remember... it works by blocking the virus from entering the body. If you wait too long, the virus has already entered the body making any type of blocking medication ineffective.

Where can you buy it?

It is available over-the-counter in most European countries and Canada. But NOT available in the United States.

The nasal spray is made by Marinomed in Europe using their Mavirex technology and also licensed for marketing/distribution by Boehringer. Carragelose is the brand name of the carrageenan ingredient. Depending on the country, the actual name of the nasal spray is sold under is different.

For example, in England, the nasal spray is called "Cold and Flu Defence Nasal Spray".

To make sure you have the right nasal spray, look under ingredients and make sure carragelose is listed.

On another note... Afrin nasal spray has also been shown to have some anti-viral activity in unpublished reports. Just be aware to not use it more than 3 days or else you may get addicted to it.


References:
Efficacy of a Carrageenan nasal spray in patients with common cold: a randomized controlled trial. Respiratory Research 2013, 14:124 doi:10.1186/1465-9921-14-124

Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold. Respir Res 2010. doi:10.1186/1465-9921-11-108

Lessons learned from a double-blind randomised placebo-controlled study with a iota-carrageenan nasal spray as medical device in children with acute symptoms of common cold. BMC Complement Altern Med 2012. doi:10.1186/1472-6882-12-147

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Does Removing the Adenoids Decrease Risk of Ear Infections? Yes...

A recent meta-analysis has determined that risk of recurrent ear infections is significantly reduced if adenoidectomy is performed in combination with ear tube placement as opposed to ear tube placement alone. When stratified by age, removing the adenoids was found particularly helpful in children older than 4 years of age.

Combining results from over 15 studies containing over 71,000 children, the estimated rate of repeat ear tube placement for recurrent ear infections in children who also had adenoidectomy was only 17.2% vs 31.8% for children undergoing ear tubes alone. However this significance faded under the age of 4 years.

Why would adenoid removal influence ear infections?

First a little anatomy lesson...

In the back of the nose, there is an opening called the eustachian tube that goes up into the ear. That's why one is able to pop the ears when blowing into a pinched nose.

Image by Chittka and Brockmann from Wikipedia

The adenoids are located in the back of the nose immediately behind the eustachian tube opening. The adenoids can potentially lead to ear problems via two mechanisms. First, the adenoids could be very enlarged causing physical obstruction of the eustachian tube which can make it impossible to pop the ears. Second, the adenoids could be a reservoir of germs which can lead to ear infections given proximity to the eustachian tube.

As such, removal of the adenoids would allow the eustachian tube to function better as well as eliminate a potential reservoir of infection.

However, recommendation for adenoid removal typically occurs if a child requires a 2nd set of tubes which usually occurs around age 4. Adenoidectomy may be recommended with the initial set of ear tubes (after taking into consideration age) if other symptoms are present including nasal obstruction and a snotty nose.


Reference:
Adenoidectomy as an Adjuvant to Primary Tympanostomy Tube Placement: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg. 2013 Nov 28. doi: 10.1001/jamaoto.2013.5842. [Epub ahead of print]

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Allergy Sufferers also Have More Severe Migraines

Many people suffer from migraines. Many people also suffer from allergies. What may have been suspected but is now clarified is that those individuals who suffer from BOTH allergies and migraines have much more frequent and severe headaches than those who do not have allergies. [link]

Based on a survey response from 5,849 patients who suffer from migraines, over two-thirds also suffered from allergies. From this group, researchers found that the odds of experiencing more frequent headaches for individuals with allergies and migraines were 33 percent greater than those suffering from migraines without allergies.

When patients were further subdivided based on the type of allergy they had (allergic, non-allergic, or both), those who suffered from both allergic and non-allergic had the most frequent and severe headaches.

Although there appears to be an association between allergies and migraine severity, the question now becomes whether the migraines themselves increase sino-nasal symptoms OR does the sino-nasal symptoms of allergies aggravate or trigger the migraine.

Based on a prior study, it is known that migraine patients under 45 years with allergies who received allergy shots had 52% less frequent and severe headaches than those who did not receive allergy shots. As such, it may be worthwhile to aggressively treat any sino-nasal symptoms in patients who suffer from migraine headaches. Such treatment may involve not just medications, but even surgery if anatomic trigger points are seen.

References:
Chronic rhinitis and its association with headache frequency and disability in persons with migraine: Results of the American Migraine Prevalence and Prevention (AMPP) Study. Cephalalgia. Published online before print November 25, 2013, doi: 10.1177/0333102413512031

Allergy and immunotherapy: are they related to migraine headache? Headache. 2011 Jan;51(1):8-20. doi: 10.1111/j.1526-4610.2010.01792.x. Epub 2010 Nov 4.

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Hearing Protection and NRR (Noise Reduction Rating)

For all hearing protection devices from ear plugs to ear muffs, there is a NRR (Noise Reduction Rating) score that informs consumers how much of a decrease in noise exposure to expect with use. For example, if an ear plug has a NRR score of 30, use of the device would be expected to reduce a 90 decibel sound by 30 decibels resulting in a noise exposure of 60 decibels.

If two hearing protection devices are used, an ear plug inside the ear canal followed by ear muffs over the ear, the ultimate noise exposure would be an additional 5 to 10 decibels greater than the higher rated NRR of the two devices.

How is NRR determined anyways? This single number rating is determined by the Environmental Protection Agency as specified under 40 CFR (Code of Federal Regulations) Part 211, Product Noise Labeling, Subpart B - Hearing Protective Devices. The raw data compiled from test subjects is than plugged into a formula which than produces the NRR:

Given that, there are MANY different types of hearing protection devices on the market. Regardless of style, most devices offer a NRR between 20-30. However, as a general rule, ear plugs typically offer a higher NRR than ear muffs. Among high NRR earplugs, disposables offer higher NRR than reusables. BUT... ear muffs typically block sound more consistently than ear plugs which require some degree of molding and fit for optimal effectiveness. Using both obviously is better than using just one.

Also, keep in mind that unless hearing protection devices are correctly fit and used properly, the attenuation suggested by NRR may not over-estimated. Indeed, lay-use of such devices without training typically result in sound attenuation far below what NRR may suggest.

The highest rated NRR disposable ear plugs are around 33:


The highest rated NRR ear muffs are around 30:

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How to Describe Hoarseness?

At heart, physicians are science geeks. And when it comes to a raspy voice, one can go truly bananas in how exactly to describe how a raspy voice sounds.

For the layperson, when asked to describe a hoarse voice, one often gets imprecise answers to a question most feel ridiculous... I often get a blank look with an answer that goes something like "You know... raspy... it's not clear." Unfortunately, such a description is inadequate. Even when using more descriptors like deeper/higher than normal, onset delays, pitch breaks, breathy, click, tight, etc, more information is needed.

There are 2 fundamental ways to more precisely convey the characteristics of how a raspy voice sounds and to document change (better/worse) over time.

Method #1 - Perceptual Tests

Developed by Dr. Robert Bastian, I personal prefer this method as it is more intuitive and replicable by anybody including the patient.

1) Maximum Phonation Time (MPT) - How many seconds can a single note be sustained for with a single breath? This test provides a rough measure of lung capacity and how "breathy" a voice is. The more breathy a voice is, the lower the MPT.
2) Pitch Range - What is the lowest and highest note a person can say/sing (I use a piano keyboard). Provides information on how much vocal cord swelling and length is present (the more swollen the vocal cords are, the deeper the pitch just like a violin string). I also typically like the patient to glide up and down from their lowest and highest note as it provides some additional information on neurological/muscular control of their voice depending on how smoothly it is performed.
3) Swell Tests - Essentially, the test involves singing a song (I use Happy Birthday) very quietly an octave higher than your normal pitch. If onset delays or pitch breaks are heard, does suggest the presence of a small bump (nodule, cyst, polyp, etc) on the vocal cords.

One can also add documentation of yell, cough, throat-clearing, and speaking voice.

Method #2 - Objective Tests

This type of testing can only be performed with the help of instruments and provides "numbers" that can be documented. It is more difficult to "hear" the voice looking at just these numbers, but does provide a more rigorous way to actually "measure" the voice quality. There are now even iPhone apps that can obtain such data.

The basic measures include:
1) Shimmer - Measures how much variation in loudness is present. Think of a volume knob being turned up and down slightly. Normal is less than 3%.
2) Jitter - Measures how much variation in pitch is present. Think of going up and down on the equalizer slightly. Normal is less than 1%.
3) MPT is also measured.
4) Fundamental frequency (f0) - Measure of how high/low a person's voice sounds (pitch).

One can go crazy and also add intensity, glottal noise, ratio, tremor, spectrum, EGG-pitch, EGG-intensity, EGG-jitter, EGG-shimmer, EGG-noise, CQ, CQ perturbation, CI, CI perturbation, opening rate, etc.

Regardless of the method, with this type of information, the actual degree and characterization of the vocal quality can be measured, documented, and tracked over time. Also, when communicating with other health professionals, such measures provide for an efficient and understandable way to describe a patent's voice with a colleague.

Of course, from the patent's perspective, they "just want to sound better," but this is how professionals do it.

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At-Home Rapid Strep Testing

Rapid strep test kits can be purchased by anybody to be done at home which may save parents/patients a lot of money in doctor visits for those prone to strep infections. Indeed, should a rapid strep test be positive, than you know that a doctor's visit is definitely worthwhile. (A doctor visit may still be worthwhile since a sore throat may be due to something else like cancer, aphthous ulcer, sinus infection, reflux, etc).

Such home kits (which in fact are the same kits used in medical offices) can be purchased online through Amazon. The price is surprisingly affordable at around the cost of a single copay $30 to do 25 tests.

However, with the purchase of such DIY kits, there are some pitfalls patients should be aware of if they decide to proceed.

1) Perform the internal controls that come with the kit!!! The kit may be a dud and needs to be tested against itself to ensure accurate results whether negative or positive. If the controls do not work, throw the whole test kit out and buy another.
2) You must follow the directions precisely, otherwise the test results will be unreliable. In other words, if the directions call for 4 drops, than it MUST be 4 drops (not 3 drops or 5). If directions state to wait 4 minutes... you must wait exactly 4 minutes. This literally is like precision baking.
3) The test strips need to be kept in protected, sealed bag and used immediately after taking one out, otherwise the test results will be unreliable.
4) When swabbing the throat, you MUST get the cotton tip on the tonsil and/or back wall of the mouth which than must be rubbed around a couple times. Getting the tongue or cheek will increase the risk of a false negative. As such, it may be worthwhile to invest in some tongue blades to help push the tongue down in order to perform this test properly.

Should patients elect to start performing home strep tests, please be aware that physicians will be obligated to not only REPEAT the testing but also examine the patient to ensure antibiotics are appropriate. An actual throat culture may be performed as well which is the gold standard test.

1) Repeat testing is required because the patient may not have followed the instructions precisely. For example, the test strips must be read at 5 minutes (variable depending on the kit). If test results are read past 5 minutes, it may incorrectly show a positive result.
2) Some patients unfortunately fabricate test results just so they can get an antibiotic without an office visit.
3) Some patients unfortunately also fabricate test results in order to skip work or school for personal reasons not related to an actual medical condition.
4) There are situations that even though the strep test is positive, no treatment may be recommended. The patient may be a strep carrier for which treatment of any kind is not recommended.

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iPhone App to Objectively Measure Vocal Quality (f0, shimmer, jitter, etc)

For the inner geek in all singers and other professional voice users, you can now download onto your iPhone an advanced voice analysis program that provides objective measures of vocal quality similar to what is obtained in a professional voice laboratory.

Called OperaVox, preliminary studies have shown good reliability compared to KayPentax Multidimensional Voice Program (f0, shimmer, jitter). Noise to harmonic ratio showed less reliability. Retest reliability was also fairly consistent in all parameters.

Developed by a team of British researchers including an ENT and an audio specialist, there are 3 version of this app including a free "lite" version, a full-featured version meant for one person, and a much more expensive multi-user version meant for professionals.

The free "lite" version provides a recording of pitch f0, jitter, and shimmer as well as a history of your last 3 tests on a graph over time.

The paid full-featured version additionally also records MPT (maximum phonation time), reading measures (pitch range, mean pitch), and singing pitch range. Historical data is presented without any limits.

The multi-user version is really applicable to professionals in order to track more than one patient/student.

For the serious voice user, this app is a worthwhile investment to objectively measure your vocal quality progress (i.e., singers) as well as to provide helpful information to a speech/voice pathologist and physician when things suddenly change or get worse.

Watch video below on how this program works.

References:
Presentation by Dr Marina Mat-Baki et al from University college London and the Royal National Throat Nose and Ear Hospital, London at Cutting Edge Laryngology 2013; “Reliability of OperaVOX as acoustic analysis software: preliminary results”

Presentation by Dr Emily Lin and Jeremy Hornibrook from the University of Canterbury, New Zealand on the suitability of the iPhone microphones for performing acoustic analyses.

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Actor Zac Efron Broke His Jaw

Image by Liam Mendes from Wikipedia

This past weekend, actor Zac Efron slipped in a puddle of water outside his home and fell resulting in a severe facial cut as well as a broken jaw. [link]

Unlike most facial fractures that do NOT require any surgical intervention, most jaw fractures do need to be surgically repaired and typically entail wiring the jaw shut. Often, a metal plate with screws will be utilized to stabilize the fracture as well.

The reason the jaw is wired shut is so that as the broken bone heals, it heals in such a way that the way the teeth comes together is normal (in essence, the teeth act as the cast for the jaw fracture). Of course, eating is limited to liquid diet and dental care is important as brushing the teeth thoroughly will be impossible.

The wires holding the jaw shut can be removed after a few weeks, but exact duration depends on the fracture location and severity.

Source:
Zac Efron broke his jaw this weekend. CNN 11/13/13

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Pediatric Sinus Development and Sinusitis

There is a tendency for any type of nasal drainage to be attributed to "sinusitis" in children. Especially in young children, "sinusitis" is a relatively rare cause for nasal drainage and congestion which is actually more commonly due to viruses and enlarged adenoids.

The reason why sinuses play a relatively minor role in nasal drainage and congestion is because sinuses are not fully developed in children. It probably is not until around the age of 7 years old that "sinusitis" starts playing a more major role in disease manifestations. And even than, viruses and enlarged adenoids still play a major role in sino-nasal discomfort and as such, antibiotics not typically warranted.

Take a look at sinus development from newborn to adulthood below. In newborns, sinuses are mere indentations in the facial bone (light green). Adult sinuses are denoted by the dark green/peach.

It is for these reasons that sinus x-rays (or radiological imaging in general) are not warranted in children under 2 years. First, there is not much there, and secondly, x-rays are notoriously poor at diagnosing true sinus pathology [more info]. From 2 years to adolescence, sinus x-rays provide some guidance as to the presence of possible sinusitis, but CT Sinus scans are the gold standard to evaluate sinus disease presence or absence.

With persistent sino-nasal symptoms in children in spite of medical management, nasal endoscopy can be performed to evaluate the nasal cavity as well as the adenoids. Initial surgical management include adenoidectomy with or without turbinate reduction. While sedated for surgery, allergy testing can also be performed. If symptoms persist after these interventions, a CT Sinus scan can be obtained and consideration for sinus surgery can be made. The reason why CT Sinus scans are not obtained earlier is because whether it comes back normal or not, management does not change unless there are unusual extenuating circumstances present (significant eye or facial swelling).

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Cure for Noise-Induced Hearing Loss?

Normally, when mammals (including humans) are exposed to very loud sounds, permanent hearing loss may result due to cochlear hair cell injury. However, an experimental drug code-named LY411575 was found to regenerate new hair cells by suppressing a protein called Notch.

In essence, this drug restored hearing to mice deafened by loud noise.

Listen to an explanation by Harvard researcher Dr. Edge in this video.

However, human trials are a very long way off… so prevention is still the best way to avoid permanent noise-induced hearing loss. Wear hearing protection whenever loud sounds may be present!

Reference:
Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma. Neuron Volume 77, Issue 1, 58-69, 9 January 2013

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Submental Intubation [video]

Holy moly... Never realized submental intubation was actually a procedure that really is performed. Check out this video (or watch below) showing a submental intubation being performed.

First, an incision is created right below the jawline slightly off from midline. Dissection is bluntly carried right to the floor of the mouth under the tongue. The endotracheal tube is than grasped and pulled through this opening resulting in a submental intubation.

Seems quick and elegant with minimal bleeding... but I have some big issues with this procedure. There are multiple avoidable risks associated with this approach including:

1) Permanent lip paralysis. The nerve that innervates the lower lip crosses right through this region.
2) Chronic submandibular sialadenitis. The duct that carries spit from the submandibular gland (one of the major glands that produce spit) to the mouth can potentally be injured resulting in stenosis and chronic salivary gland inflammation if not infection.
3) Permanent numbness of the bottom of the mouth. The nerve that provides sensation to the region under the tongue crosses right through this area.
4) Permanent tongue paralysis. The nerve that allows for tongue movement crosses through this area.

Rather than a submental intubation, why not perform a tracheostomy or cricothyroidotomy. With either of these alternative procedures, the risks are minimal (there is no risk of nerve damage).

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ENT Doctor iPhone App Games

This was bound to happen sooner or later… thanks to @hobsonent who brought this to my attention.

This Nose Doctor iPhone app game basically is to try and remove nasal hair as well as boogers from different characters' noses using different instruments.

Another iPhone app game is Ear Doctor which deals more with ear problems (obviously).

Although these iPhone apps makes a game out of it, do ENT doctors actually professionally remove boogers, earwax, and nasal hair? We do… Regularly… For real… We are indeed professional ear and nose-pickers.

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What are Hot Dogs Made of? Pathological Analysis...

Ever since the publication of The Jungle by Upton Sinclair in 1906 about the US meat industry, there has been a negative connotation on what hot dogs are actually made of. Urban legend will report anything and everything can potentially be found in a hot dog including rats, human extremities, feces, etc.

So this begs the question of what really is found inside a hot dog when looked under the microscope to bring light of truth upon this murky question.

in 2008, Ohio pathologists took a look at 8 different brands of hot dogs and this is what they found:

• The average meat content in a hot dog was only 5.7% (range 2.9% - 21%). Water actually made up most of a hot dog content consisting of 57% (range 44% - 69%). What meat was seen was recognizable as muscle, but did show evidence of degenerative changes. Also, the higher the meat content, the more expensive the hot dog was.

• No brain tissue was seen in any samples (especially important when considering mad-cow disease is localized in brain tissue and can be transmitted to humans who eat contaminated tissue causing fatal Crutzfeldt-Jakob disease).
• Besides meat, other tissue types were seen including connective tissue, blood vessels, nerves, and fat (all expected in meat/muscle).
• However, cartilage and bone was also found in some samples, perhaps accrued during the butchering and processing of the meat.
• Unexpectedly, skin was found in one hot dog. Plant material was also unexpectedly found which may have been added as a way to add bulk to the meat.

There you have it!

What about hamburger meat? Click here for more info...

Reference:

Applying morphologic techniques to evaluate hotdogs: what is in the hotdogs we eat? Ann Diagn Pathol. 2008 Apr;12(2):98-102. doi: 10.1016/j.anndiagpath.2007.04.012. Epub 2007 Oct 24.

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Exactly What is Fast Food Hamburger Meat Made of? Pathological Analysis...

I freely admit that in my youth, I loved eating burgers from fast food joints like McDonald's. But after getting married and being encouraged to eat healthier by my wife who felt fast food burgers were unhealthy (disgusting) because they weren't actually made of meat, I've always wondered what hamburger meat was truly made of...

Well... a group of pathologists actually performed a pathologic analysis on 8 different fast food hamburger meat. No... they did not identify the fast food chain where they got the meat.

What they found was both reassuring as well as alarming. Here are the key interesting findings:

• Actual meat content in a typical burger is only 12% (range: 2.1%-14.8%). The meat itself did appear normal which is reassuring. Most of the burger is actually made of water comprising 49% of the weight (range: 37%-62%)
• No brain tissue was seen in any samples (especially important when considering mad-cow disease is localized in brain tissue and can be transmitted to humans who eat contaminated tissue causing fatal Crutzfeldt-Jakob disease).
• Besides meat, other tissue types were seen including connective tissue, blood vessels, nerves, and fat (all expected in meat/muscle).
• However, cartilage and bone was also found in some samples, perhaps accrued during the butchering and processing of the meat.
• Plant material was also unexpectedly found which may have been added as a way to add bulk to the meat.
• Intracellular parasites (Sarcocystis) was also seen in a few samples which is why meat should always be cooked prior to eating (whether burger or restaurant grade A meat).

So there you have it... fast food hamburger meat actually does contain meat, though it only makes a small part of it.

What about hot dogs? Click here for more info...

Reference:
Fast food hamburgers: what are we really eating? Annals of Diagnostic Pathology 12 (2008) 406–409

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Nasacort Steroid Nasal Spray to be Available Over-The-Counter!

Sanofi announced today that the FDA has approved Nasacort steroid nasal spray to be made available over-the-counter (OTC) starting sometime spring 2014.

Nasacort is a steroid nasal spray used to treat allergies in patients start from the age of 2 years old. It will also be the very first steroid nasal spray made OTC in the United States which can be both a blessing as well as a curse.

Why?

With Nasacort going OTC which will certainly make it more convenient for patients, I also anticipate that the other prescription steroid nasal sprays including nasonex, qnasl, zetonna, veramyst, etc will become much harder to prescribe due to insurance requiring patients to use OTC Nasacort first. Worst case, insurance may even simply stop paying for the prescription steroid nasal sprays.

After all, this is exactly what happened with prescription reflux and anti-histamine medications.

Source:
FDA Approves Sanofi's Nasacort(R) Allergy 24HR for Over-the-Counter Use. Wall Street Journal 10/11/13

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Surgeons Should be Good at Social Media

Not just surgeons, but also any procedural intensive medical specialties like interventional cardiology and radiology should be reasonably good at social media.

Why?

Because we have built-in time points within our daily routine schedule that enable such activities.

Let me explain... Between every surgical case, there is downtime that lasts anywhere from 15 minutes to as long as 45 minutes.

It is the time during which the operating room is being cleaned, sterilized, and new instruments are brought in and set up.

Before the days of social media, this is the time when many surgeons would read the newspaper/magazine, eat in the cafeteria, surf the internet, chat with staff, etc. Of course, any consults and paperwork that are pending would first be addressed.

But now... this time can be used for social media activities.

This time can now be used to read/write blogs, read/post tweets, and generally think of ideas worthy of sharing.

OR... if you are just sitting there waiting for a surgical case to start, check out my tweets or blog!

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First Implantation of Human Artificial Larynx Announced!

Image taken from DNA

ProTip SAS and Strasbourg University Hospitals announced that a fully artificial larynx was implanted into a human for the first time.

Made entirely of titanium, the surgery was performed in two stages into a man with throat cancer that required his entire voicebox to be removed (laryngectomy).

Stage 1:
In June 2012, the larynx was removed and a titanium tracheal ring was implanted in its place.

Stage 2:
In November 2012, a removable valve-based device was inserted into/onto the titanium tracheal ring via the mouth.

According to reports, this device allows for both breathing as well as phonation.

What is still unclear to me from reports scavenged on the internet are the following questions which I'm sure will become more clear as more information is provided:

1) What does the voice sound like?
2) How is breathing and phonation exactly accomplished?
3) How much is swallowing impacted?
4) What is the risk of extrusion?
5) How is the valve constructed to enable voice production?
6) How is aspiration prevented during swallow?


Source:
ProTip and Strasbourg University Hospitals announce the first human implantation of an artificial larynx. MNT 10/9/13

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Ear Tube Placement in Kids WITHOUT Sedation (Starting at 12 Months of Age)

A recent report describes how using a relatively old technology, ear tube placement can now be performed in children starting at 12 months of age with chronic ear infections or hearing loss due to fluid buildup without the need for sedation of any kind nor aggressive restraints (ie papoose). Historically, ear tube placement in the office without sedation is typically performed starting at around 12 years of age using standard local anesthesia techniques. Any younger, a child could not be trusted to stay still during the procedure due to presence of some discomfort.

In any case, a Texan ear group reports how they accomplished this simple procedure at such young ages.

First, the ear canal is cleaned as much as possible of all earwax and debris. The ear canal is than filled with an anesthetic liquid (concoction of lidocaine, epinephrine, and sodium bicarbonate). Over 10 minutes, iontophoresis was than used to induce profound local anesthesia to the ear canal and eardrum. The liquid was than suctioned out and ear tube placement was performed with a reported 90% success rate (78 of 86 ears; 17 subjects were 3 years old or younger; 8 were 12 months old).

The key to success required 3 "new" elements.

• Iontophoresis device made by Acclarent. There are other iontophoresis devices in the market (Medtronic and Otomed), but none adapted for simultaneous bilateral ear canal usage that works within 10 minutes. Iontophoresis works by applying a gentle electric current in order to actively move charged drug molecules into the skin. In this particular case, positively charged lidocaine and epinephrine.
• Optimal anesthetic solution for iontophoresis. Dubbed "EMGIM", it contains 1:12,000 epinephrine with 3.3% lidocaine hydrochloride and 0.7% sodium bicarbonate. The solution is prepared fresh prior to use by combining 10 mL of 4% lidocaine hydrochloride with 1 mL of 1:1,000 epinephrine. After mixing the lidocaine and epinephrine, 1 mL of 8.4% sodium bicarbonate is added.
• Ear tube delivery device and placement system. Typically, a competent ENT can place an ear tube in about 10-20 seconds. However, when dealing with kids who may potentially move unexpectedly and operating within a very small ear canal space, a faster and more reliable way of placing a tube was required. Hence, this new device. [link]

Of course, during the actual procedure, age-appropriate distraction was needed to minimize movement, especially given aggressive restraint was not used.

Sounds great as sedation is something to be avoided if at all possible. However, there is one problem... the Acclarent iontophoresis device is NOT yet FDA approved contrary to what the report states (direct communication with Acclarent executives October 1, 2013). Hopefully in 2014. As such, beyond a research setting, this in-office technique is not yet available for use in the United States.

As an aside, there are FDA-approved iontophoresis devices for use in pediatric head and neck surgical procedures mainly for sub-cutaneous mass excisions and abscess incision and drainage. Check out Phoresor for such applications using lidocaine infused electrodes. It's even sold on Amazon.


References:
Otologic Iontophoresis: A No-Papoose Technique. Annals of Otology. Rhinology & Laryngology 122(8):487-491. Aug 2013.

In-Office Tympanostomy Tube Placement Under Local Anesthesia Using a Novel Tube Delivery Device. Triological Meeting Poster. Dec 2012.

Iontophoresis: a needle-free, electrical system of local anesthesia delivery for pediatric surgical office procedures. J Pediatr Surg. 1999 Jun;34(6):946-9.

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